کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139723 | 1087913 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia](/preview/png/2139723.png)
Repetitive elements are heavily methylated in normal tissues, but hypomethylated in malignant tissues, driving the global genomic hypomethylation found in cancer. This hypomethylation results in chromosomal instability, a well-characterized feature of the advanced phases of chronic myeloid leukemia (CML). We investigated methylation changes of DNA repetitive elements (LINE1, Alu, Satellite-alpha and Satellite-2) during the progression of CML from chronic phase (CP) to blast crisis (BC). CP-CML samples were significantly more hypomethylated for all repetitive sequences compared with normal samples. Furthermore, a more profound level of hypomethylation was observed among BC samples compared with CP samples. Our data suggest that repetitive DNA hypomethylation are closely associated with CML progression.
Journal: Leukemia Research - Volume 32, Issue 3, March 2008, Pages 487–490