کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139975 | 1087922 | 2006 | 7 صفحه PDF | دانلود رایگان |
Minimal residual disease (MRD) was measured by RQ-PCR in 11 AML1/ETO and 13 CBFβ/MYH11 patients at diagnosis, after induction chemotherapy, and at all subsequent visits. Median detection limits were 1:50,000 and 1:10,000, respectively. In 64/103 samples MRD was detectable and highly correlated in PB and BM. In 38/103 samples, where MRD was only detectable in BM, median BM MRD was 3.5 log lower than at diagnosis. Event free survival was significantly inferior in case of <2 log reduction post-induction MRD. Persistent MRD was always followed by hematological relapse. Molecular progression rate in relapsing CBFβ/MYH11 was surprisingly slow with a time lag to hematological relapse approaching 1 year. This direct comparison between the two subgroups of CBF AMLs delineates clear biological differences and corroborates the value of RQ-PCR.
Journal: Leukemia Research - Volume 30, Issue 4, April 2006, Pages 389–395