Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung

• The cancer cells and stromal cells are immunostained in LPA.
• Invasive potential of cancer cells is increased in noninvasive component of MIA.
• At the progression from MIA to LPA-S, microenvironmental molecular changes occur.

ObjectivesInvasive lepidic predominant adenocarcinoma (LPA) of the lung is thought to progress in a stepwise fashion from adenocarcinoma in situ (AIS) and min