کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2140853 1088267 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Important prognostic factors for lung cancer in tobacco predominant Eastern North Carolina: Study based on a single cancer registry
ترجمه فارسی عنوان
مهمترین عوامل پیش آگهی برای سرطان ریه در توتون غالب شرق کارولینای شمالی: مطالعه بر اساس یک رجیستری تنها سرطان
کلمات کلیدی
سرطان ریه، مسابقه، اثرات بیمه، بافت شناسی، رجیستر سرطان، تناقض
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

BackgroundIt is known that lung cancer incidence and mortality rate are higher in African Americans (AA) than whites. In Eastern North Carolina, there is a higher percentage of AA population than the national average (30.2% vs. 12.4%) and a higher incidence of lung cancer in this region. We investigated demography and survival of lung cancer patients diagnosed and treated in a single institution.MethodsThe study includes 2351 patients diagnosed with lung cancer between 2001 and 2010 at East Carolina University. AA and whites were compared by age, sex, race, stage, histology, smoking history and insurance information using chi-square analyses. Patient survival was modeled using Cox proportional hazards regression (SAS version 9.2).ResultsThe distribution of lung cancer was 70% in whites and 30% in AA. The proportion of AA and whites differed significantly for age, sex, histology, stage, and insurance. Patients aged >70 (p < 0.0001) and 51–70 (p = 0.0064) died sooner than those ≤50 years old. Compared with squamous cell, SCLC had inferior survival (HR = 2.0, 95%CI = 1.7–2.3). Privately insured patients survived longer than those with medicare (p < 0.0001), medicaid (p = 0.0009), or no insurance (p < 0.0001). The survival disadvantage for medicaid (p = 0.0076) and no insurance (p = 0.0033) persisted on multivariable analysis. Race was not a significant predictor of survival on multivariable analysis (p = 0.66).ConclusionThis is one of the largest lung cancer patient populations from a single institution showing demographic differences between the two races with similar survival outcome. Age, histology and type of insurance were strong predictors of survival outcome. Older age, small cell histology and medicaid and no insurance had significantly shorter overall survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 84, Issue 2, May 2014, Pages 116–120
نویسندگان
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