کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2142174 1088310 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung
چکیده انگلیسی

IntroductionNapsin A is regarded as a marker of lung adenocarcinoma. However, no comprehensive analyses of napsin A-positive lung ADCs or the prognostic significance of napsin A expression have been reported to date.Methods110 primary lung adenocarcinoma cases were analyzed for clinicopathologic parameters, including overall survival, stage, histology, napsin A and TTF-1 expression, EGFR mutation, and ALK rearrangement.ResultsNapsin A-positive adenocarcinomas were significantly more prevalent among tumors characterized as relatively small (p = 0.023), non-solid predominant (p < 0.001), non-mucinous/enteric (p < 0.001), positive for TTF-1 expression (p < 0.001), and positive for EGFR mutation (p = 0.001). Multivariate analysis of overall survival demonstrated that the absence of napsin A was an independent prognostic factor for reduced survival time (p = 0.002).ConclusionClinicopathologic characteristics associated with napsin A-positive lung ADC are similar to and overlap with those of TTF-1-positve ADCs. The absence of napsin A is an independent poor prognostic factor in surgically resected adenocarcinoma. Further studies are necessary to determine the role of napsin A in the progression of lung adenocarcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 77, Issue 1, July 2012, Pages 156–161
نویسندگان
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