کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2142520 1088319 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diminished lipocalin-type prostaglandin D2 synthase expression in human lung tumors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Diminished lipocalin-type prostaglandin D2 synthase expression in human lung tumors
چکیده انگلیسی

Previously, we demonstrated that lipocalin-type prostaglandin D2 synthase (L-PGDS) induces apoptosis and prevents cell cycle progression in several cell types. In this study we determined the expression of L-PGDS in a variety of human lung tumor types. While L-PGDS expression was evident in the surrounding margins, we observed significantly decreased protein and gene expression in the tumor tissue. Using RT-PCR we demonstrated that L-PGDS gene expression decreased proportionately with tumor progression. In addition, we demonstrated that exogenously added L-PGDS could suppress the hyperproliferation and PDGF-stimulated migration of A549 cells, a cultured carcinomic human alveolar basal epithelial cell line. We conclude that L-PGDS may play a key role in modulating lung cancer growth and may offer a novel diagnostic and therapeutic approach for treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 70, Issue 1, October 2010, Pages 103–109
نویسندگان
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