کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143403 1088346 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Docetaxel plus gemcitabine as front-line chemotherapy in elderly patients with lung adenocarcinomas: A multicenter phase II study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Docetaxel plus gemcitabine as front-line chemotherapy in elderly patients with lung adenocarcinomas: A multicenter phase II study
چکیده انگلیسی

SummaryBackgroundThe docetaxel/gemcitabine (DG) combination is an active and well-tolerated regimen against non-small cell lung cancer (NSCLC). A phase II study was conducted in order to evaluate its efficacy in elderly patients with lung adenocarcinomas.MethodsChemotherapy-naive patients, aged ≥70 years, with locally advanced or metastatic lung adenocarcinomas and performance status (PS) ≤2 (ECOG) received gemcitabine 1100 mg/m2 (days 1 + 8) and docetaxel 100 mg/m2 (day 8) with rhG-CSF support.ResultsSeventy-seven patients were enrolled. One (1.3%) complete and 23 (29.9%) partial responses were achieved (intention to treat analysis: ORR 31.2%; 95% CI 20.82–41.51%) whereas tumor growth control was achieved in 53.3% of patients. The median TTP was 4.1 months, the median overall survival 9.4 months and the 1- and 2-year survival rate 37.9% and 10.7%, respectively. Grade 3–4 neutropenia occurred in 18.2% and febrile neutropenia in 3 (3.9%) patients. Non-haematological toxicity was mild with grade 2–3 asthenia occurring in 22.1% patients.ConclusionsThe DG regimen is an active and well-tolerated front-line chemotherapy for elderly patients with lung adenocarcinomas and merits further evaluation in prospective randomized trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 63, Issue 1, January 2009, Pages 77–82
نویسندگان
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