کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143450 1088348 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain
چکیده انگلیسی

SummaryPolymorphisms in tumor suppressor genes might contribute to the individual susceptibility to develop different types of cancer. Alterations in genes involved in cell cycle regulation and apoptosis, as tumor suppressor gene TP53, can lead to malignant transformations increasing the risk of developing cancer. We have investigated effects of polymorphism Arg72Pro on lung cancer risk, focusing on smoking and histology. Our study is a hospital-based case-control study designed with 589 lung cancer patients mainly with squamous cell carcinoma (215), adenocarcinoma (156) and small cell carcinoma (90), and 582 control subjects, matched in ethnicity, age and gender. Genotypes were determined by PCR-RFLP and the results were analysed using multivariate unconditional logistic regression, adjusted for age, gender and smoking status. The analysis showed a statistically significant increase of lung cancer risk in Pro carriers (Arg/Pro and Pro/Pro) (adjusted OR = 1.32; 95% CI = 1.03–1.69), especially for ever smokers (adjusted OR = 1.34; 95% CI = 1.04–1.73), heavy smokers (adjusted OR = 1.48; 95% CI = 1.01–2.16) and smokers of exclusively black tobacco (adjusted OR = 1.45; 95% CI = 1.04–2.00). Moreover, Pro carriers present an increased risk of developing small cell lung cancer (adjusted OR = 1.70; 95% CI = 1.07–2.69) and cancer in stage IV for NSCLC (adjusted OR = 1.56; 95% CI = 1.07–2.27). Our results suggest that polymorphism Arg72Pro in tumor suppressor gene TP53 increases the risk of lung cancer. The effect is especially strong for small cell lung cancer (SCLC) and heavy smokers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 61, Issue 3, September 2008, Pages 309–316
نویسندگان
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