کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143486 1088350 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phase II trial of gemcitabine/carboplatin followed by paclitaxel in patients with performance status = 2,3 or other significant co-morbidity (HIV infection or s/p organ transplantation) in advanced non-small cell lung cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Phase II trial of gemcitabine/carboplatin followed by paclitaxel in patients with performance status = 2,3 or other significant co-morbidity (HIV infection or s/p organ transplantation) in advanced non-small cell lung cancer
چکیده انگلیسی

SummaryIntroductionThe role of chemotherapy in patients with advanced non-small cell lung cancer and poor performance status or who have HIV disease or organ transplantation is unclear. While survival appears to be enhanced, serious toxicity may occur. We evaluated the efficacy of sequential, dose attenuated carboplatin/gemcitabine followed by paclitaxel in patients with PS = 2,3, HIV infection or after solid organ transplantation.Patients and methodsChemotherapy naive patients with PS 2,3 or who were HIV positive or post solid organ transplantation were eligible. Treatment consisted of gemcitabine: 1000 mg/m2 d 1,8 carboplatin: AUC = 5 d 1 q 21d × 2 followed by paclitaxel 80 mg/m2 q wk × 6 followed by a 2 week break and then repeated until progression.Results47 patients were entered. Stage IIIb/IV: 8/39, PS 2/3 = 26/19, HIV infection = 2, solid organ transplantation = 2. 12 (25%) had brain metastases. Thirty-nine patients completed two cycles of carboplatin/gemcitabine and 29 pts received at least one cycle of paclitaxel. Overall response rate was 19% (95% CI 1.2–31.7%). Median event free, overall and 1-year survivals were 3.3 months, 5.8 months and 8.4%. Toxicity was moderate with 19% experiencing grade 4 neutropenia (11% with febrile neutropenia).ConclusionsSequential carboplatin/gemcitabine to paclitaxel is well tolerated and active in this population. The survival seen is comparable to that of other regimens utilized in PS = 2 patients with superior tolerability however, the prognosis for these patients is very poor even with treatment. This is the first trial to prospectively evaluate chemotherapy for patients with HIV disease or organ transplantation and NSCLC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 61, Issue 1, July 2008, Pages 61–66
نویسندگان
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