کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143840 1088361 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of matrix metalloproteinases 7 and 9 in non-small cell lung cancer: Relation to clinicopathological factors, β-catenin and prognosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Expression of matrix metalloproteinases 7 and 9 in non-small cell lung cancer: Relation to clinicopathological factors, β-catenin and prognosis
چکیده انگلیسی

SummaryMatrix metalloproteinases (MMPs) have been shown to have a significant role in determining cancer cell behaviour. The present study was undertaken to analyze the expression and prognostic value of MMP-7 and MMP-9 in non-small cell lung cancer (NSCLC). The relationship of MMP-7 with β-catenin was also evaluated.The study consists of 212 patients with resected NSCLC. Tumour samples were stained immunohistochemically, and the expression of MMP-7 and MMP-9 was evaluated in both tumour cells and peritumoural stromal tissue. The results were compared to clinicopathological factors of the patients. A high staining of MMP-7 and MMP-9 in tumour cells was noted in 62 (30%) and 113 (57%) cases, respectively. Expression of MMP-7 was noted more often in adenocarcinomas than in other histological types (p = 0.022). High cancer cell associated MMP-7 was related to lower T-factor (p = 0.037), better tumour differentiation (p = 0.005) and normal β-catenin expression in tumour cells (p = 0.001). A high MMP-9 expression in tumour cells was related to poor tumour differentiation (p = 0.016). The stromal signal for MMP-9 was observed in 58 (32%) cases and was linked with higher tumour grade (p = 0.031). In survival analyses the significant predictors of survival were histological type of tumour and tumour stage (p = 0.0009 and 0.0012, respectively). MMP-7 or MMP-9 signals were not related to patient's outcome.The results show that high MMP-9 expression indicates aggressive, and high MMP-7 less aggressive tumour behaviour in NSCLC. However, MMP-7 and MMP-9 expressions had no prognostic value in NSCLC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 51, Issue 3, March 2006, Pages 313–321
نویسندگان
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