کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143977 1088367 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Defective expression of transforming growth factor β type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Defective expression of transforming growth factor β type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma
چکیده انگلیسی

SummaryLarge cell carcinoma (LCC) of the lung is defined as an undifferentiated carcinoma without the characteristic features of squamous cell (SqC), small cell, or adenocarcinomas (AdC). In the present study, the expression level of the important tumor suppressor, transforming growth factor β type II receptor (TGFBR2), was examined both in LCC and non-LCC tumors, which include AdC, SqC and adenosquamous carcinoma (Ad-SqC). Immunohistochemical staining with TGFBR2 antibody revealed statistically significant or near significant differences in the reduced expression in LCC (80% of cases) versus AdC (42.1% of cases, P = 0.0288) and SqC (47.1% of cases, P = 0.0589), or LCC versus non-LCC (45% of cases, P = 0.02). The differences in the expression level of TGFBR2 between LCC and non-LCC were consistent with the histopathologic classification of these tumors, suggesting that the defective TGFBR2 expression might contribute to the carcinogenesis and/or development of LCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 58, Issue 1, October 2007, Pages 36–43
نویسندگان
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