کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2144090 1088371 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain
چکیده انگلیسی

SummaryBackgroundLung cancer is the leading cause of cancer deaths in most countries. In patients with metastases, such as the brain, the 1-year survival is 10% and most of these patients die in 1–3 months. Data from large phase II trials of non-small cell lung cancer (NSCLC) suggested that the histologic subtype of adenocarcinoma may be a prognostic factor for patients treated with gefitinib. To evaluate the efficacy of gefitinib in palliative therapy for advanced patients with adenocarcinoma and brain metastases, we conducted a phase II study.Patients and methodsEligible patients had histologically confirmed adenocarcinoma and brain metastases confirmed with radiological studies. All eligible patients had undergone chemotherapy previously. From December 2003 to December 2004, 40 patients received 250 mg doses of gefitinib daily. The symptomatic response, survival, and toxicity were recorded.ResultsThe overall objective response rate was 32% with a disease control rate of 77%. Altogether, 45% of the patients experienced symptom improvement. The median progression-free survival and overall survival were 9.0 months and 15.0 months, respectively. Gefitinib was well-tolerated, with cutaneous reactions as the most frequent toxicity.ConclusionsOur data suggest that gefitinib has promising activity in palliative therapy for patients with advanced lung adenocarcinoma and brain metastasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 57, Issue 3, September 2007, Pages 359–364
نویسندگان
, , , , , ,