کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2144143 1088374 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population
چکیده انگلیسی

SummaryBackgroundThe FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (−1377G>A and −670A>G) and FASL (−844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case–control study in a Korean population.MethodsThe FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender.ResultsThe FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer.ConclusionThese results suggest that the FAS−1377G>A and −670A>G and FASL−844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 54, Issue 3, December 2006, Pages 303–308
نویسندگان
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