کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2144230 1088377 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer
چکیده انگلیسی

SummaryPurposeInsulin-like growth factor (IGF) system is related to cell proliferation and tumor growth. We tested whether pretreatment plasma levels of IGF-1, IGF-2, and IGF binding protein (IGFBP)-3 would predict the prognosis in patients with advanced non-small cell lung cancer (NSCLC).MethodsPlasma levels of IGF-1, IGF-2, and IGFBP-3 were measured using enzyme-linked immunoassays from 77 patients with advanced NSCLC enrolled in a phase II study of irinotecan plus cisplatin chemotherapy.ResultsIGF-2 and IGFBP-3 levels were elevated in female patients, non-squamous cell carcinoma, and never smokers. In a univariate Cox proportional hazards model, higher levels of IGF-1, IGF-2, and IGFBP-3 were predictive of longer progression-free (P = 0.001, 0.006, and 0.007, respectively) and overall survival (P = 0.025, <0.0001, and 0.001, respectively). Multivariate analysis revealed that IGF-1 and IGFBP-3 are independent factors for progression-free survival (P < 0.0001 and P = 0.001, respectively). In addition, IGF-1, IGF-2, and IGFBP-3 are independently predictive for overall survival (P = 0.004, 0.001, and 0.043, respectively).ConclusionsHigh plasma levels of IGF-1, IGF-2, and IGFBP-3 were associated with good prognosis in patients with advanced NSCLC. Further validation of these results is needed to determine the prognostic significance of IGF system in advanced NSCLC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 54, Issue 2, November 2006, Pages 227–234
نویسندگان
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