کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2146435 | 1548344 | 2013 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The yin and yang of repair mechanisms in DNA structure-induced genetic instability The yin and yang of repair mechanisms in DNA structure-induced genetic instability](/preview/png/2146435.png)
DNA can adopt a variety of secondary structures that deviate from the canonical Watson–Crick B-DNA form. More than 10 types of non-canonical or non-B DNA secondary structures have been characterized, and the sequences that have the capacity to adopt such structures are very abundant in the human genome. Non-B DNA structures have been implicated in many important biological processes and can serve as sources of genetic instability, implicating them in disease and evolution. Non-B DNA conformations interact with a wide variety of proteins involved in replication, transcription, DNA repair, and chromatin architectural regulation. In this review, we will focus on the interactions of DNA repair proteins with non-B DNA and their roles in genetic instability, as the proteins and DNA involved in such interactions may represent plausible targets for selective therapeutic intervention.
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volumes 743–744, March–April 2013, Pages 118–131