Genotypes, haplotypes and diplotypes of three XPC polymorphisms in urinary-bladder cancer patients

PurposeThe XPC gene is involved in DNA damage recognition in the nucleotide excision repair pathway (NER). We investigated the additive effects of single nucleotide polymorphisms (SNPs) in bladder-cancer patients and population controls for three XPC polymorphisms: A499V (C > T), K939Q (A > C), and poly AT (PAT, −/+).Experimental Design311 bladder-cancer patients from a population-based cohort and 337 population controls were genotyped using the PCR-restriction fragment length polymorphism (RFLP) technique.ResultsWe found complete linkage between the K939Q (A > C) and PAT (−/+) polymorphisms and therefore only the K939Q (A > C) polymorphism was included in analyses. The over all estimated odds ratio was 1.7 (95% CI 1.3–2.4) for A499V (C > T