Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks

PurposeThe majority of cancer patients will receive radiotherapy (RT), therefore, investigations into advances of this modality are important. Conventional RT dose intensities are limited by adverse responses in normal tissues and a primary goal is to ameliorate adverse normal tissue effects. The aim of these experiments is to further our understanding regarding the mechanism of radioprotection by the DNA minor groove binder, methylproamine, in a cellular context at the DNA level.Materials and methodsWe used immunocytochemical methods to measure the accumulation