کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2147413 | 1548416 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of linkage between lymphotoxin α haplotype and polymorphisms in 5â²-flanking region of tumor necrosis factor α gene associated with efficacy of infliximab for Crohn's disease patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Tumor necrosis factor (TNF)α is increased in patients with Crohn's disease (CD) and considered to play an important role in the inflammation. Infliximab (IFX) is used as a therapeutic agent for CD. Recently, it was reported that homozygosity for a lymphotoxin α (LTA) haplotype (LTA 1-1-1-1) may identify subgroups with a poor response to IFX. In the present study, we characterized the linkage of the LTA haplotype with SNPs in the 5â²-flanking region of the TNFα gene. In subjects who had homozygosity for each LTA haplotype, 6 nucleotide variations, â857C > T, â522C > G, â357A > C, â261C > G, â159G > T and â96G > T, were found in the 5â²-flanking region of the TNFα gene. As for linking with the allele, only â857T met the LTA haplotype 1-1-1-1. We concluded that the differences in therapeutic effects of IFX among patients with CD may be explained in part by the induction ability of TNFα via the â857C > T polymorphism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 602, Issues 1â2, 1 December 2006, Pages 170-174
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 602, Issues 1â2, 1 December 2006, Pages 170-174
نویسندگان
Takeshi Ozeki, Yoko Furuya, Chieko Nagano, Chika Matsui, Risa Takayanagi, Haruko Yokoyama, Yasuhiko Yamada,