Dihydroxyselenolane (DHS) supplementation improves survival following whole-body irradiation (WBI) by suppressing tissue-specific inflammatory responses

• DHS treatment improved the 30 days survival of irradiated (WBI, 8Gy) mice by 40%.
• DHS treatment led to tissue specific induction of GPx1, GPx2 and GPx4.
• DHS treatment suppressed radiation induced inflammatory responses in lung and intestine.
• The radioprotective effect of DHS was comparable with that of selenomethionine.

Dihydroxyselenolane (DHS), a simple water-soluble organoselenium compound, was evaluated for radioprotection in BALB/c mice after whole-body irradiation (WBI) (8 Gy 60Co, 1 Gy/min), by monitoring 30-d post-irradiation survival and biochemical/histological changes in radiosensitive organs. Intraperitoneal administration of DHS at 2 mg/kg for five consecutive days before irradiation an