کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2148909 1548632 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GSTM1 polymorphism along with PM10 exposure contributes to the risk of preterm delivery
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
GSTM1 polymorphism along with PM10 exposure contributes to the risk of preterm delivery
چکیده انگلیسی

We investigated the association between the risk of preterm delivery and each metabolic gene of glutathione S-transferases mu 1 (GSTM1), theta 1 (GSTT1) and cytochrome P450IA1 (CYP1A1) along with exposure to particulate matter <10 μm (PM10). This study was assumed to identify gene–environment interaction that increases the risk of preterm delivery. A case–control study was carried out on 117 women with preterm deliveries and 118 women with term deliveries in Seoul, Korea. Logistic regression analyses were performed to explore the impact of each gene, PM10 exposure and their interaction on the risk of preterm birth. The risk of preterm birth was associated with the GSTM1 null genotype only. Exposure to high levels of PM10 (≥75th percentile) during the third trimester of pregnancy was associated with an increased risk of preterm birth when compared to low-level exposure to PM10 (<75th percentile). We found that exposure to high levels of PM10 during the third trimester in the presence of the GSTM1 null genotype is significantly associated with the risk of preterm delivery. This finding is biologically plausible and provides evidence for a gene–environment interaction that increases the risk of preterm birth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 656, Issues 1–2, 30 October 2008, Pages 62–67
نویسندگان
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