کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2149007 | 1548636 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX](/preview/png/2149007.png)
Polycyclic aromatic hydrocarbons (PAHs), wide-spread mutagenic and carcinogenic environmental pollutants, are consistently exposed to sunlight in the environment. The exposure causes structural change, resulting in the generation of a variety of photomodified products having different bioactivities compared with the parent compounds. In this study, we found that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL)-induced phosphorylation of histone H2AX (γ-H2AX), which was recently identified as an early event after the induction of DNA double strand breaks (DSBs). Although BaP itself did not produce γ-H2AX, SSL-exposed BaP significantly generated γ-H2AX depending on the period of exposure. Furthermore, we revealed that reactive oxygen species produced by the SSL-exposed BaP mainly contributed to the generation of γ-H2AX. The appearance of γ-H2AX means the induction of the most serious form of DNA damage, DSBs, suggesting the potential risk of carcinogenesis.
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 650, Issue 2, 29 February 2008, Pages 132–139