کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2149439 | 1089620 | 2006 | 6 صفحه PDF | دانلود رایگان |
Vanillin (VA), the world's major flavoring compound used in food industry and confectionery products – that has antimutagenic and anticarcinogenic activity against a variety of mutagenic/carcinogenic agents – was tested for the interval between the formation of premutational lesion and it is finalization as a DNA lesion. The overall findings using co-treatment protocols in SMART test suggest that VA can lead to a significant protection against the general genotoxicity of ethylmethanesulphonate (EMS), N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU) and bleomycin sulphate (BLEO). Considering MNU, ENU and EMS the desmutagenic activity observed could result from VA-stimulation of detoxification, via induction of glutathione S-transferase. However, the protector effect related to BLEO could be attributed to its powerful scavenger ability, which has the potential to prevent oxidative damage induced by BLEO.
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 607, Issue 2, 5 September 2006, Pages 225–230