کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2149483 | 1548646 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clastogenicity of the fungicide afugan in cultured human lymphocytes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Clastogenicity of the fungicide afugan in cultured human lymphocytes Clastogenicity of the fungicide afugan in cultured human lymphocytes](/preview/png/2149483.png)
چکیده انگلیسی
The genotoxic effects of the fungicide afugan were analysed by measuring chromosomal aberrations (CAs), sister chromatid exchange (SCE) and micronuclei (MN) in cultured human peripheral lymphocytes. Concentrations of 2.5, 5, 10 and 20 μg/ml of afugan were used during 24 and 48 h. Afugan significantly increased the frequency of CAs at 5, 10 and 20 μg/ml concentrations during a 48 h treatment period. A significant increase was observed for induction of SCE and MN at all treatments compared with the negative control. A significant dose-response correlation was found in all tests. Afugan did not affect the replicative index (RI), however it significantly decreased the mitotic index (MI) at all treatment concentrations except 2.5 μg/ml, and at both treatment times. The present results indicate that afugan is clastogenic and cytotoxic to cultured human lymphocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 604, Issues 1â2, 30 April 2006, Pages 53-59
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 604, Issues 1â2, 30 April 2006, Pages 53-59
نویسندگان
Deniz YüzbaÅıoÄlu, Mustafa Ãelik, Serkan Yılmaz, Fatma Ãnal, Hüseyin Aksoy,