کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2153833 1090206 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An alumina ceramic target vessel for the remote production of metallic radionuclides by in situ target dissolution
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
An alumina ceramic target vessel for the remote production of metallic radionuclides by in situ target dissolution
چکیده انگلیسی

IntroductionAs the use of metallic radionuclides increases, so does the demand for a simple production method. In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device.MethodsAn alumina ceramic vessel for a vertical irradiation system was designed and developed. The ceramic vessel was evaluated by the production of Zr-89 using an yttrium powder target. The irradiated Y was dissolved remotely in HCl in the ceramic vessel and transferred as a solution to a hotcell through a Teflon tube. The crude Zr-89 was then purified by an automated apparatus. The Zr-89 was eluted with 100 μL of oxalic acid (solution) as the final product.ResultsThe ceramic vessel gave a sufficient yield of Zr-89 (57 ± 11 MBq/μAh), showed good operability, and could be reused up to 10 times. With nominal irradiation (10 μA × 2 h) in ~ 90 μL, the product (~ 940 MBq) was obtained with > 99.9% radionuclidic purity.ConclusionThe combination of the ceramic vessel and vertical irradiation has great potential for the remote production of various metallic radionuclides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 39, Issue 8, November 2012, Pages 1281–1285
نویسندگان
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