کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2154148 | 1090219 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, radiolabeling, biodistribution and fluorescent imaging of histidine-coupled hematoporphyrin Synthesis, radiolabeling, biodistribution and fluorescent imaging of histidine-coupled hematoporphyrin](/preview/png/2154148.png)
IntroductionHematoporphyrin (Hp) and hematoporphyrin derivatives (HpDs) have been widely used as photosensitizers in photodynamic therapy (PDT). Radiolabeling of HpDs is helpful for preclinical and clinical studies of PDT.MethodsThe histidine-coupled hematoporphyrin (His-Hp) was synthesized and radiolabeled with [99mTc(CO)3(H2O)3]+. Biodistribution of the radioligand and fluorescent imaging of His-Hp in mice bearing S180 tumor were investigated.Results[99mTc(CO)3]+-labeled His-Hp was electrically neutral, hydrophilic and stable. The biodistribution of the radioligand in S180 tumor-bearing mice was similar with that of nonlabeled HpD in the literature. The uptake of His-Hp in tumors and livers was confirmed by fluorescent imaging.ConclusionsThe complex [99mTc(CO)3]+–His-Hp might be suitable for in vivo dose evaluation of HpD in PDT.
Journal: Nuclear Medicine and Biology - Volume 39, Issue 4, May 2012, Pages 579–585