کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2154223 1090223 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET
چکیده انگلیسی

IntroductionTo clarify the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD) in living patients, positron emission tomography (PET) with [62Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([62Cu]ATSM) was applied to functional imaging of oxidative stress mainly due to mitochondrial dysfunction in the striata of patients with PD.MethodsFifteen PD patients who presented with lateral dominant symptoms at onset and six healthy controls underwent [62Cu]ATSM PET. Dynamic PET data acquisition was performed, and standardized uptake values (SUVs) were obtained from the delayed phase of dynamic data by means of region of interest analysis. The striatum-to-cerebellum SUV ratio (S/C ratio) was calculated from the SUV in all subjects of the striatum and the cerebellar cortex.ResultsThe mean S/C ratio of the bilateral striata of the patients (1.15±0.10) was significantly increased compared with that of the controls (1.08±0.02) (P<.05). In the patients, the S/C ratio of the bilateral striata showed a positive correlation with the Unified Parkinson's Disease Rating Scale (UPDRS) rating (r=0.52, P<.05), and the S/C ratio of the striatum contralateral to the initially affected body side showed a strong positive correlation with the UPDRS rating (r=0.62, P<.05).Conclusions[62Cu]ATSM PET imaging demonstrated that striatal oxidative stress was enhanced in PD patients compared with the controls and increased with the progression of disease severity, particularly in the contralateral striatum. These findings indicated that oxidative stress associates with striatal neurodegeneration in PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 38, Issue 7, October 2011, Pages 945–951
نویسندگان
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