کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2154674 1090246 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serotonin transporter and dopamine transporter imaging in the canine brain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Serotonin transporter and dopamine transporter imaging in the canine brain
چکیده انگلیسی

The serotonergic and dopaminergic systems are involved in a wide range of emotional and behavioral aspects of animals and humans and are involved in many neuropsychiatric disorders. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are designed to block the 5-HT transporter (SERT), thereby increasing the available 5-HT in the brain. Functional imaging with specific SERT and dopamine transporter (DAT) ligands contributes to the study of the SSRI–transporter interaction.First, we evaluated the feasibility of a canine model in the study of the SERT and DAT with the radioligands [123I]-β-CIT and [123I]-FP-CIT as well as single-photon emission computed tomography imaging. Second, we studied the effect of SSRIs (sertraline, citalopram and escitalopram) on the SERT and DAT in two dogs.The position of the canine model in the study of the SERT and DAT is discussed and compared with other animal models.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 33, Issue 7, October 2006, Pages 907–913
نویسندگان
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