کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2154752 1090250 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo monitoring of intranuclear p27kip1 protein expression in breast cancer cells during trastuzumab (Herceptin) therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
In vivo monitoring of intranuclear p27kip1 protein expression in breast cancer cells during trastuzumab (Herceptin) therapy
چکیده انگلیسی
[111In]-Anti-p27kip1-tat may be useful for monitoring changes in the expression of the intranuclear protein, p27kip1. Up-regulation of p27kip1 resulted in increased retention of [111In]-anti-p27kip1-tat in cells treated with trastuzumab. Modest, but statistically significantly higher, retention was also observed in tumours in mice treated with trastuzumab. Since responsiveness to trastuzumab correlated to up-regulation of p27kip1, it may be possible to use [111In]-anti-p27kip1-tat to guide treatment with Herceptin and other drugs which alter p27kip1 expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 36, Issue 7, October 2009, Pages 811-819
نویسندگان
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