کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2154885 | 1090259 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biodistribution of 3â²-fluoro-5-[131I]iodo-2â²-deoxyuridine: a comparative study of [131I]FLIdU and [18F]FLT
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biodistribution of 3â²-fluoro-5-[131I]iodo-2â²-deoxyuridine: a comparative study of [131I]FLIdU and [18F]FLT Synthesis and biodistribution of 3â²-fluoro-5-[131I]iodo-2â²-deoxyuridine: a comparative study of [131I]FLIdU and [18F]FLT](/preview/png/2154885.png)
چکیده انگلیسی
The radioiodinated 3â²-fluorothymidine (FLT) analogue 3â²-fluoro-5-[131I]iodo-2â²-deoxyuridine ([131I]FLIdU) was synthesized, with iodine mimicking the methyl group of pyrimidine. [131I]FLIdU was accessible by direct electrophilic iodination using Iodogen as oxidant. Optimized amounts of the oxidant allowed radiochemical yields of about 70% after a reaction time of 10 min in an aqueous buffer medium at 90°C. The uptake of [131I]FLIdU in a DoHH2 leukemia xenograft mouse model and in healthy mice revealed moderate FLIdU accumulation, followed by a significant washout of activity in proliferating tissues such as splenic and tumor tissues. In contrast, intraperitoneal coinjection with [18F]FLT showed high uptake and high activity retention up to 2 h, in both splenic and tumor tissues. Uptake in stomach tissues and increasing fractions of [131I]iodide in urine indicated metabolic instability of [131I]FLIdU due to rapid deiodination. Therefore, [131I]FLIdU alone does not seem to be a promising compound, neither for diagnostic imaging nor for potential therapeutic applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 34, Issue 3, April 2007, Pages 273-281
Journal: Nuclear Medicine and Biology - Volume 34, Issue 3, April 2007, Pages 273-281
نویسندگان
Andreas T.J. Vogg, Andreas K. Buck, Michaela Schmid, Bernd Neumaier, Katrin Wczasek, Boris D. Zlatopolskiy, Sven N. Reske,