کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2154910 1090262 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC
چکیده انگلیسی

IntroductionImaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of 68Ga-DOTATOC and PET/CT.MethodsIn this work, a purification method for the 68Ge/68Ga generator eluate and a method to produce 68Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the 68Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry.Results68Ga-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3±2.8% (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98% and 99.9999%, respectively. With this purification process, >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution.Conclusions68Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 35, Issue 6, August 2008, Pages 721–724
نویسندگان
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