کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2155018 1090375 2016 6 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
GATA-3 expression is not associated with complete pathological response in triple negative breast cancer patients treated with neoadjuvant chemotherapy
ترجمه فارسی عنوان
بیان GATA-3 با پاسخ کامل پاتولوژیک در بیماران مبتلا به سرطان منفی سه گانه سینه منجر تحت درمان با شیمی درمانی نئوادجوانانت در ارتباط نیست
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

ObjectiveThe prognosis for patients with triple negative breast cancer (TNBC) is poor, however, a subset will demonstrate complete pathological response (pCR) to chemotherapy. GATA-3 and AR may be a negative predictors for pCR although it is unclear if these results apply to TNBC.MethodsPatients diagnosed with TNBC and treated with neoadjuvant chemotherapy were identified. Immunohistochemistry was performed for GATA-3 and AR. Both were scored using a composite of staining intensity and percentage cells stained. The primary outcome was pCR.ResultsTwenty-four patients were included and 7 achieved pCR. There was no difference in the pre-chemotherapy tumor size (44 ± 28 mm vs. 54 ± 30 mm; p = 0.764) or lymph node status (86% vs. 71%; p = 0.629) between patients with and without pCR. GATA-3 expression was present in 20 cases (83%) while AR was present in 6 cases (25%). No AR expression was seen in 15 cases (63%) with GATA-3 positivity. There was no difference in either GATA-3 (4.3 ± 2.7 vs. 3.6 ± 2.5; p = 0.549) or AR (1.4 ± 2.5 vs. 1.1 ± 2.4; p = 0.778) expression between patients with and without pCR.ConclusionsGATA-3 expression is frequent in TNBC even in the absence of AR. However, neither GATA-3 nor AR are associated with pCR after neoadjuvant chemotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 212, Issue 6, June 2016, Pages 539–544
نویسندگان
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