کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
217695 | 1426419 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Optimization of cultivation conditions for fungichromin production from Streptomyces padanus PMS-702 Optimization of cultivation conditions for fungichromin production from Streptomyces padanus PMS-702](/preview/png/217695.png)
A novel strain, Streptomyces padanus PMS-702, was employed to produce fungichromin (FC, a polyene macrolide antibiotic) in a shake flask cultivation. In comparing the effects of various carbon and nitrogen sources on PMS-702 cultivation, it was found that glucose and soybean meal medium yielded the highest FC within 2 days. Factors such as medium composition, cultivation temperatures, and initial pH were optimized for FC production with response surface methodology (RSM). The optimal cultural condition obtained is as follows: glucose 11.2 g/L, soybean meal 11.2 g/L, CaCO3 0.46 g/L, temperature 31.7 °C, and an initial pH 5.5. Under these conditions, FC production reached 112 mg/L, about an increase of 2.86 times, as compared to results under basic conditions.
Journal: Journal of the Chinese Institute of Chemical Engineers - Volume 39, Issue 1, January 2008, Pages 67–73