کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2178097 1549625 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population
چکیده انگلیسی

BackgroundThe Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1).AimTo investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India.MethodsIn the present study, we have collected CKD patients (n = 147) and control subjects (n = 211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers.ResultsThe DD genotype is associated with the female population (OR-CI = 2.40 (1.05–5.51), p = 0.04) as compared to the male population (OR-CI = 0.75 (0.37–1.51), p = 0.42). Further, we found the over representation of “I” – allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) – 0.58 (0.32–1.04), p = 0.07] which suggests its protective role in male population.ConclusionThe DD genotype of ACE is associated with CKD in south India.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Medical Human Genetics - Volume 16, Issue 1, January 2015, Pages 29–33
نویسندگان
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