کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182944 1095532 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates
چکیده انگلیسی

Serum H-ficolin (ficolin-3) concentrations (n = 613) and FCN3 genotypes (n = 529) from a large group of neonates are presented. Both pre-term deliveries and low birthweight (independently of gestational age) were significantly associated with low H-ficolin concentrations but not with heterozygosity for the FCN3 1637delC frameshift mutation. The presence of the variant allele, however, apparently influenced the protein level. No association of FCN3 gene heterozygosity or relative functional H-ficolin insufficiency (determined as serum level ≤8.6 μg/ml) with perinatal infections was found. One premature newborn, with confirmed infection caused by Streptococcus agalactiae, was H-ficolin-deficient (FCN3 variant homozygote, no detectable protein). We present what is only the fourth case report of total H-ficolin deficiency in the world literature. This neonate was however previously found to be mannan-binding lectin (MBL) as well as MBL-associated serine protease-2 (MASP-2) deficient and also had low serum L-ficolin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 217, Issue 7, July 2012, Pages 730–737
نویسندگان
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