کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2183085 | 1095544 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection](/preview/png/2183085.png)
Genetic interactions between natural killer (NK) cells immunoglobulin-like receptor (KIR) genes and immunoglobulin allotypes have been previously reported in type 2 diabetes mellitus (DM) patients. Puerto Rican Americans with a history of intravenous drug use who developed DM following HCV infection (n = 32) were compared to individuals infected with HCV without diabetes (n = 121) and to DM non-infected individuals (n = 95). Subjects were genotyped for KIRs and immunoglobulin allotypes. We found interactions of immunoglobulin allotypes KM3/KM3 with NK inhibitory receptors 2DL3/2DL3, 2DL1 in the absence of 2DS4 associated with susceptibility to DM in HCV infected individuals. These data suggest the possibility that a subset of patients with HCV could have an immune-mediated component contributing to the development of DM.
Journal: Immunobiology - Volume 216, Issue 6, June 2011, Pages 686–691