کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2183214 1095556 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A defect of CD16-positive monocytes can occur without disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
A defect of CD16-positive monocytes can occur without disease
چکیده انگلیسی

The CD16-positive monocytes have been first described in 1988 but to date no selective defect in the number of these cells in blood has been reported. We now describe a family in which three of four siblings lack both CD16-positive monocyte subsets, i.e. the nonclassical and the intermediate monocytes. All three had CD16-positive monocytes of 2 cells/μl or less as compared to 52 ± 18 cells/μl in healthy controls.The index case was affected by recurrent pleural effusion and infections and had evidence of an auto-inflammatory condition but no mutation of any of the relevant candidate genes. The other two siblings without CD16-positive monocytes were apparently healthy. There was no defect in serum M-CSF levels and no mutation in the M-CSF and M-CSFR genes.The data indicate that the absence of CD16-positive monocytes in blood does not lead to disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 218, Issue 2, February 2013, Pages 169–174
نویسندگان
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