کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2183214 | 1095556 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A defect of CD16-positive monocytes can occur without disease A defect of CD16-positive monocytes can occur without disease](/preview/png/2183214.png)
The CD16-positive monocytes have been first described in 1988 but to date no selective defect in the number of these cells in blood has been reported. We now describe a family in which three of four siblings lack both CD16-positive monocyte subsets, i.e. the nonclassical and the intermediate monocytes. All three had CD16-positive monocytes of 2 cells/μl or less as compared to 52 ± 18 cells/μl in healthy controls.The index case was affected by recurrent pleural effusion and infections and had evidence of an auto-inflammatory condition but no mutation of any of the relevant candidate genes. The other two siblings without CD16-positive monocytes were apparently healthy. There was no defect in serum M-CSF levels and no mutation in the M-CSF and M-CSFR genes.The data indicate that the absence of CD16-positive monocytes in blood does not lead to disease.
Journal: Immunobiology - Volume 218, Issue 2, February 2013, Pages 169–174