کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2183288 1095561 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement dysregulation and disease: From genes and proteins to diagnostics and drugs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Complement dysregulation and disease: From genes and proteins to diagnostics and drugs
چکیده انگلیسی

During the last decade, numerous studies have associated genetic variations in complement components and regulators with a number of chronic and infectious diseases. The functional characterization of these complement protein variants, in addition to recent structural advances in understanding of the assembly, activation and regulation of the AP C3 convertase, have provided important insights into the pathogenic mechanisms involved in some of these complement related disorders. This knowledge has identified potential targets for complement inhibitory therapies which are demonstrating efficacy and generating considerable expectation in changing the natural history of these diseases. Comprehensive understanding of the genetic and non-genetic risk factors contributing to these disorders will also result in targeting of the right patient groups in a stratified medicine approach through better diagnostics and individually tailored treatments, thereby improving management of patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 217, Issue 11, November 2012, Pages 1034–1046
نویسندگان
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