کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2184170 1550304 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MHC class II molecules in tumour immunology: Prognostic marker and target for immune modulation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
MHC class II molecules in tumour immunology: Prognostic marker and target for immune modulation
چکیده انگلیسی
MHC class II molecules presenting MHC class II restricted antigens play an important role in the activation of CD4+ T cells, which are the central orchestrating cells of an immune response. This review focuses on the particular role of MHC class II molecules in tumour immunology. The MHC class II antigen presentation pathway and the expression of MHC class II molecules on tumour cells related to clinical outcome is discussed. Improving the MHC class II tumour antigen presentation pathway, for instance by downregulation of the invariant chain or modulation of HLA-DO expression, offers many opportunities for developing new modalities of immunotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 211, Issues 6–8, 14 September 2006, Pages 619-625
نویسندگان
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