Rare disease relations through common genes and protein interactions

• Orphan disease connections (ODCs) is a resource to explore potential molecular relations between rare diseases.
• Disease relations are based on disease susceptibility genes and human protein-protein interactions.
• Users can search, retrieve and explore in detail disease relations as well as other clinical data.
• ODCs relations can be used to transfer knowledge between diseases and look for synergies between research lines.

ODCs (Orphan Disease Connections), available at http://csbg.cnb.csic.es/odcs, is a novel resource to explore potential molecular relations between rare diseases. These molecular relations have been established through the integration of disease susceptibility genes and human protein-protein interactions. The database currently contains 54,941 relations between 3032 diseases.