Separation of amoxicillin using trioctylmethylammonium chloride via a hollow fiber supported liquid membrane: Modeling and experimental investigation

• HFSLM can successfully extract and strip amoxicillin from aqueous solutions.
• A high percentage of extraction was obtained reaching 85.21%.
• A high percentage of stripping was obtained reaching 80.34%.
• The mass-transfer coefficients (kf) and (km) were 3.57 × 10−2 and 0.70 × 10−2 cm/s, respectively.
• Experimental data and theoretical values were found to be in good agreement.

The separation experiments of amoxicillin via hollow fiber supported liquid membrane (HFSLM) were performed under various operating conditions to find the optimal parameters i.e. pH, feed concentration, carrier concentration, and flow rates of feed and stripping solution. Percentages of extraction and recovery of amoxicillin from the feed phase reached 85.21% and 80.34%, respectively. The aqueous-phase mass transfer coefficient (kf) and organic-phase mass transfer coefficient (km) were reported to be 3.57 × 10−2 and 0.70 × 10−2 cm/s, respectively. Furthermore, a mathematical model was developed to predict the concentration of amoxicillin at different times. The results showed promising agreement with experimental data.

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