کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
226792 | 464807 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kinetic resolution of amines by (R)-selective omega-transaminase from Mycobacterium vanbaalenii
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Kinetic resolution of amines by (R)-selective omega-transaminase from Mycobacterium vanbaalenii Kinetic resolution of amines by (R)-selective omega-transaminase from Mycobacterium vanbaalenii](/preview/png/226792.png)
چکیده انگلیسی
Recently (R)-selective ω-transaminase ((R)-ω-TAMV) from Mycobacterium vanbaalenii was discovered and utilized for the asymmetric synthesis of (R)-amines from its corresponding ketones. In this study, (R)-ω-TAMV was used for the kinetic resolution of racemic amines to produce (S)-amines. (R)-ω-TAMV showed very low product inhibition by ketone product (acetophenone), which is beneficial for carrying out the kinetic resolution of racemic amines with high concentration. 100 mM racemic amines were successfully resolved into (S)-amines (>99% ee) by (R)-ω-TAMV with pyruvate. In addition, the kinetic resolution of α-MBA was successfully carried out by using acetone as an amino acceptor which is cheaper than pyruvate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Industrial and Engineering Chemistry - Volume 23, 25 March 2015, Pages 128–133
Journal: Journal of Industrial and Engineering Chemistry - Volume 23, 25 March 2015, Pages 128–133
نویسندگان
Giyoung Shin, Sam Mathew, Hyungdon Yun,