Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications

Antiproliferative drug (sirolimus or propolis) loaded lipid polymer hybrid nanospheres (LPHNSs) were prepared by single step method. The effects of different lipids on properties of nanocarrier were investigated. Furthermore, anti proliferative efficiency and cytotoxicity of LPHHNSs-propolis or sirolimus were investigated on human aortic smooth muscle cells (HASMCs), and human aortic endothelial primary cells (HAECs) respectively. The characterization of LPHNSs revealed that the lipids used in the formulation influence physiochemical parameters. In vitro studies showed that the encapsulated sirolimus and propolis significantly reduced the proliferation of HASMCs, while maintaining high HAECs viability.

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