کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
227891 | 464830 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Green synthesis of anisotropic silver nanoparticles and its potential cytotoxicity in human breast cancer cells (MCF-7)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
We described a green, cost effective and rapid method for synthesizing anisotropic AgNPs using a novel bacterium called Escherichia fergusoni. Furthermore, synthesized AgNPs were characterized by various analytical techniques. The present study demonstrates the efficiency of biologically synthesized AgNPs as a cytotoxic agent against MCF-7 cells and also this study investigates possible molecular mechanisms underlying the cytotoxic effects of AgNPs. AgNPs showed dose dependent cytotoxicity against MCF-7 cells through activation of the lactate dehydrogenase (LDH), reactive oxygen species (ROS) generation and eventually leading to induction of apoptosis which was further confirmed through resulting nuclear fragmentation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Industrial and Engineering Chemistry - Volume 19, Issue 5, 25 September 2013, Pages 1600–1605
Journal: Journal of Industrial and Engineering Chemistry - Volume 19, Issue 5, 25 September 2013, Pages 1600–1605
نویسندگان
Sangiliyandi Gurunathan, Jae Woong Han, Ahmed Abdal Dayem, Vasuki Eppakayala, Jung Hyun Park, Ssang-Goo Cho, Kyung Jin Lee, Jin-Hoi Kim,