کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
227891 464830 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Green synthesis of anisotropic silver nanoparticles and its potential cytotoxicity in human breast cancer cells (MCF-7)
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Green synthesis of anisotropic silver nanoparticles and its potential cytotoxicity in human breast cancer cells (MCF-7)
چکیده انگلیسی

We described a green, cost effective and rapid method for synthesizing anisotropic AgNPs using a novel bacterium called Escherichia fergusoni. Furthermore, synthesized AgNPs were characterized by various analytical techniques. The present study demonstrates the efficiency of biologically synthesized AgNPs as a cytotoxic agent against MCF-7 cells and also this study investigates possible molecular mechanisms underlying the cytotoxic effects of AgNPs. AgNPs showed dose dependent cytotoxicity against MCF-7 cells through activation of the lactate dehydrogenase (LDH), reactive oxygen species (ROS) generation and eventually leading to induction of apoptosis which was further confirmed through resulting nuclear fragmentation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Industrial and Engineering Chemistry - Volume 19, Issue 5, 25 September 2013, Pages 1600–1605
نویسندگان
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