کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
227958 464831 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dendritic multi-walled carbon nanotube with thermoresponsive shells: A good carrier for anticancer drugs
ترجمه فارسی عنوان
نانولوله کربنی چندجداره دندریتیک با پوسته گرماسپس: حامل خوب برای داروهای ضد سرطان
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی

In this research, multi-walled carbon nanotubes (MWCNTs) were modified by dendritic macromonomer. Herein, polyamidoamine with acrylamide end groups was incorporated on MWCNTs. Afterwards, poly(N-isopropylacrylamide), (PNIPAM), was grafted on polyamidoamine in a facile synthesis. Then, doxorubicin as anticancer drug was loaded on this nanocarrier. The drug release was studied at below and above the lower critical solution temperature of PNIPAM, (LCST 32 °C), 27 °C and 37 °C, respectively. At 37 °C (body temperature) the polymer shell dehydrated and the drug release increased. The profile of drug release was expressed by Higuchi's equation which indicated that the drug release mechanism was diffusion controlled.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Industrial and Engineering Chemistry - Volume 35, 25 March 2016, Pages 332–340
نویسندگان
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