کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
227975 | 464832 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: l-Menthol crystal micronized by rapid expansion of supercritical carbon dioxide l-Menthol crystal micronized by rapid expansion of supercritical carbon dioxide](/preview/png/227975.png)
Rapid expansion of supercritical solutions (RESS) is a promising alternative for micronizing various materials including l-menthol of which dissolution would be mainly controlled by its particle size and morphology. The aim of this work is to study the effect of ethanol co-solvent, pre-expansion temperature and pre-expansion pressure on the size and morphology of l-menthol crystals micronized by rapid expansion of supercritical CO2 in prior to their microencapsulation. Calculation of l-menthol dissolution in supercritical CO2 (SC-CO2) was conducted, suggesting that the appropriate pre-expansion temperature would be below 50 °C. Verification based on FT-IR analysis suggested that the fine particles of l-menthol crystals with controlled size and morphology could be prepared by rapid expansion of supercritical CO2 without any structural change.
Journal: Journal of Industrial and Engineering Chemistry - Volume 18, Issue 3, 25 May 2012, Pages 904–908