کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
228052 | 464833 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Catalytic transfer hydrogenation of 7-ketolithocholic acid to ursodeoxycholic acid with Raney nickel
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Catalytic transfer hydrogenation of 7-ketolithocholic acid to ursodeoxycholic acid with Raney nickel Catalytic transfer hydrogenation of 7-ketolithocholic acid to ursodeoxycholic acid with Raney nickel](/preview/png/228052.png)
چکیده انگلیسی
Ursodeoxycholic acid was produced by the stereoselective reduction of 7-ketolithocholic acid. This hydrogenation reaction was catalyzed by the T-1 Raney nickel and potassium borohydride was used as hydrogen donor instead of inflammable hydrogen gas. Potassium tert-butoxide was introduced to improve yield of ursodeoxycholic acid from about 70% to a maximum of 94% by inducing the stereoselectivity on hydroxyl group at 40 °C and atmospheric pressure. Reduction reaction conditions such as amount of reactants, temperature and stirring speed were optimized. The whole process is safe and low-cost. Eventually, the product, ursodeoxycholic acid was characterized by IR, 1H NMR and 13C NMR spectra.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Industrial and Engineering Chemistry - Volume 19, Issue 2, 25 March 2013, Pages 606–613
Journal: Journal of Industrial and Engineering Chemistry - Volume 19, Issue 2, 25 March 2013, Pages 606–613
نویسندگان
He Tian, Hongbin Zhao, Xuejun Cao,