کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
229229 | 464863 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Acylation of salicylamide to 5-acetylsalicylamide using ionic liquids as dual catalyst and solvent Acylation of salicylamide to 5-acetylsalicylamide using ionic liquids as dual catalyst and solvent](/preview/png/229229.png)
The Lewis acidic ionic liquids, 1-butyl-3-methylimidazolium chloroaluminate ([BMIM]Cl-nAlCl3) and N-butylpyridinium chloroaluminate ([BPy]Cl-nAlCl3), were used as both catalyst and solvent in Friedel–Crafts acylation of salicylamide with acetyl chloride to 5-acetylsalicylamide. The Lewis acidic ionic liquids, substituting for the conventional carcinogenic nitrobenzene solvent and anhydrous AlCl3 catalyst, showed excellent catalytic activity in the acylation of salicylamide to 5-acetylsalicylamide. When [BMIM]Cl-2AlCl3 was used as the catalyst, the yield of 5-acetylsalicylamide reached 81.3%. When [BPy]-2AlCl3 was used as the catalyst, the maximum yield of 5-acetylsalicylamide was 89.2%. The content of AlCl3 and the structure of the cations in the ionic liquids had synergistic effect on the acylation reaction.
Journal: Journal of Industrial and Engineering Chemistry - Volume 16, Issue 5, 25 September 2010, Pages 800–804