کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
229432 | 465028 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, characterization, antimicrobial and anticancer studies of new steroidal pyrazolines
ترجمه فارسی عنوان
سنتز، خصوصیات، مطالعات ضد میکروبی و ضد سرطان جدید پریآزولین های استروئیدی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
A convenient synthesis of 2′-(2″,4″-dinitrophenyl)-5α-cholestano [5,7-c d] pyrazolines 4–6 from cholest-5-en-7-one 1–3 was performed and structural assignment of the products was confirmed on the basis of IR, 1H NMR, 13C NMR, MS and analytical data. The synthesized compounds were screened for in vitro antimicrobial activity against different strains during which compound 6 showed potent antimicrobial behaviour against Corynebacterium xerosis and Staphylococcus epidermidis. The synthesized compounds were also screened for in vitro anticancer activity against human cancer cell lines during which compound 5 exhibited significant anticancer activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 20, Issue 1, January 2016, Pages 7–12
Journal: Journal of Saudi Chemical Society - Volume 20, Issue 1, January 2016, Pages 7–12
نویسندگان
Shamsuzzaman, Hena Khanam, Ayaz Mahmood Dar, Nazish Siddiqui, Sumbul Rehman,