Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents

A novel series of 2-Chloroquinoline nucleus clubbed with the pyrazole ring has been synthesized and screened for antibacterial and antifungal activity. The results obtained were promising against both bacterial and fungal strains.   Among the series, compound MB-N was found moderately active against Aspergillus fumigatus, Penicillium notatum and Bacillus subtilis having MIC 48, 46 and 44 μg/ml, respectively whereas compound MB-A was found active against P. notatum, B. subtilis and Escherichia coli having MIC 57, 54 and 43 μg/ml, respectively as compared to standard.