کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
229669 465039 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue
چکیده انگلیسی

In the present work, carbonyl pyridoquinolones 8–33 were synthesized and their ability to inhibit gram-positive stains Bacillus subtilis and Staphylococcus aureus, gram-negative stains Escherichia coli and Pseudomonas aeruginosa, and fungi Candida albicans was studied. Carbonyl piperazines attached at C-3 position of pyridoquinolone exhibited good antibacterial activity when compared to the standard drugs ciprofloxacin and gatifloxacin. Indeed carbonyl piperazine derivatives 24–32 when attached at the C-3 position of pyridoquinolone increased the activity of their parent compound 6 than that of carbonyl ureas 8–23 exhibited lower antibacterial activity compared to carbonyl piperazine derivatives 24–32.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 15, Issue 2, April 2011, Pages 167–176
نویسندگان
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