کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
229669 | 465039 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
In the present work, carbonyl pyridoquinolones 8–33 were synthesized and their ability to inhibit gram-positive stains Bacillus subtilis and Staphylococcus aureus, gram-negative stains Escherichia coli and Pseudomonas aeruginosa, and fungi Candida albicans was studied. Carbonyl piperazines attached at C-3 position of pyridoquinolone exhibited good antibacterial activity when compared to the standard drugs ciprofloxacin and gatifloxacin. Indeed carbonyl piperazine derivatives 24–32 when attached at the C-3 position of pyridoquinolone increased the activity of their parent compound 6 than that of carbonyl ureas 8–23 exhibited lower antibacterial activity compared to carbonyl piperazine derivatives 24–32.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 15, Issue 2, April 2011, Pages 167–176
Journal: Journal of Saudi Chemical Society - Volume 15, Issue 2, April 2011, Pages 167–176
نویسندگان
Navin B. Patel, Jaymin C. Patel, Sandip H. Modi,